Sr. Research Investigator

Sr. Research Investigator

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning. As an employer Penn has been ranked nationally on many occasions with the most recent award from Forbes who named Penn one of America's Best Large Employers in 2023.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title
Sr. Research Investigator

Job Profile Title
Research Investigator, Senior

Job Description Summary
The Armellino Center of Excellence for Williams Syndrome at Penn and CHOP is seeking a Senior Research Investigator, who will initiate, contribute and manage development of multiple research projects and study protocols of Dr. Mark Levin. Dr. Levin's studies are focused on cardiovascular manifestation of Williams syndrome, with specific emphasis on sudden cardiac death. Selected candidate will be leading the animal studies, conducting electrophysiology experiments, including those requiring experience with patch clamp technique. To ensure success of all researches/clinical studies, Senior Research Investigator will work with Principal Investigator, Dr. Mark Levin, and will closely interact with post doctoral fellows and students in the laboratory, as well as will participate in developing and following safety procedures and research SOPs and protocols for general
laboratory practices, in compliance with safety regulations. It is anticipated that Senior Research Investigator will assist with preparation of conference presentations and with preparation of drafts of manuscripts to submitted to peer-reviewed journals.

Job Description

The Senior Research Investigator will initiate, contribute and manage development of multiple research projects and study protocols of Dr. Mark Levin. Dr. Levin's studies are focused on cardiovascular manifestation of Williams syndrome, with specific emphasis on sudden cardiac death. Selected candidate will be leading the animal studies, including whole animal, organ level and isolated cardiomyocyte electrophysiology experiments. These include in vivo cardiac electrophysiology testing, optical mapping with voltage and calcium sensitive dyes and isolated cardiomyocyte studies using whole cell patch clamp, mycoyte contractility and calcium imaging techniques. To ensure success of all researches/clinical studies, Senior Research Investigator will work with Principal Investigator, Dr. Mark Levin, and will closely interact with postdoctoral fellows and students in the laboratory, as well as will participate in developing and following safety procedures and research SOPs and protocols for general laboratory practices, in compliance with safety regulations. It is anticipated that Senior Research Investigator will assist with preparation of conference presentations and with preparation of drafts of manuscripts to submitted to peer-reviewed journals. Desired individual will both plan experiments, troubleshoot commonly occurring problems and should be able to interpret data quality and results.

Duties will include but not limited to:

• Experimental design
• Conducting experiments at the bench
• Conducting animal experiments
• Data analysis
• Preparing manuscripts
• Presenting data at conferences and appropriate professional meetings
• Perform additional duties as assigned

**Contingent upon funding**

Qualifications

• Doctor of Medicine, Doctor of Philosophy, and 5 to 7 years of post doc experience is required.
• Expertise in designing and carrying out cellular and whole animal elcetrophysiology experiments involving optical mapping with voltage sensitive dyes, isolating ventricular myocytes from murine models for use in whole-cell patch clamp studies and calcium transient recordings and in vivo mouse cardiac electrical studies using programmed electrical stimulation. PREFERRED

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$79,500.00 - $100,000.00 Annual Rate
Salary offers are made based on the candidate's qualifications, experience, skills, and education as they directly relate to the requirements of the position, and in alignment with salary ranges based on external market data for the job's level. Internal organization and peer data at Penn are also considered.

Equal Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state or local law.

Special Requirements
Background checks may be required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits

• Health, Life, and Flexible Spending Accounts : Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
• Tuition : Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
• Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
• Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
• Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
• Wellness and Work-life Resources : Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
• Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
• University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
• Discounts and Special Services : From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
• Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
• Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
• Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.

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Equal Employment Opportunity Statement

The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.
To apply, visit

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