Postdoctoral Research Fellow Cancer Immunotherapy, Radiotherapy, and Microbiome Modulation
Open Date: Sep 12, 2025
Deadline: The Facciabene Lab at the University of Pennsylvania (Department of Radiation Oncology, Abramson Cancer Center) is recruiting a highly motivated Postdoctoral Research Fellow to join our translational research program at the intersection of cancer immunotherapy, radiotherapy (RT), and microbiome modulation . Our group investigates how the gut microbiome shapes systemic immune responses to RT and CAR-T cell therapy , and explores mitochondrial tumor-associated antigens (TAMAs) as novel targets for immune intervention. We combine preclinical tumor models, mechanistic immunology, and correlative human studies to develop microbiome-targeted interventions and next-generation immunotherapies. Responsibilities:
- Design and perform mechanistic studies in murine tumor models, including CAR-T + RT combinations and microbiome modulation (antibiotics, FMT, LBPs, IgY antibodies).
- Apply advanced immunological techniques (multi-color flow cytometry, ELISPOT, cytokine/chemokine profiling, immune phenotyping of TME and peripheral blood).
- Perform microbiome and metabolomic analyses in collaboration with the Penn/CHOP Microbiome Program (experience in metagenomic analysis would be a plus).
- Contribute to the development of mitochondrial antigen-based immunotherapies and vaccines.
- Collaborate closely with clinical investigators on ongoing and upcoming NIH-funded clinical trials.
- Analyze data, prepare manuscripts, and present findings at internal meetings and international conferences.
Required:
- PhD (or MD/PhD) in Immunology, Cancer Biology, Microbiology, Bioengineering, or related field.
- Hands-on experience with mouse tumor models and in vivo immune experiments.
- Demonstrated proficiency in cellular immunology techniques (e.g., T cell assays, flow cytometry, molecular cloning, CRISPR, or related).
- Strong publication record in immunology, oncology, or microbiome research.
- Excellent organizational, communication, and teamwork skills.
Interested applicants should submit the following materials through Interfolio:
Curriculum Vitae (CV)
Cover letter describing research experience, career goals, and fit with the lab's focus areas (cancer immunotherapy, radiotherapy, microbiome, mitochondrial immunology)
Contact information for 3 references (letters will be requested later if needed)
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