Principal Scientist (Renal Disease)

Site Name: USA - Pennsylvania - Upper Providence

Posted Date: Jan 21 2026

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.

Find out more: Our approach to R&D

As a Principal Scientist in the Biology Unit, working in Renal Disease, you will play a critical role in bridging preclinical and early clinical proof of concept studies by designing and performing validation and translational assays in human-derived cells, tissues, and biofluids.

This is a lab-based position with mandatory on-site presence at the Upper Providence, Pennsylvania (USA).

Key Responsibilities:

• Design and execute laboratory experiments to advance scientific understanding and support drug discovery in renal disease.
• Support identification and validation of new targets and development of translational assays.
• Apply expertise in multiple capabilities such as ELISA/MSD, Western/JESS, flow cytometry, gene/protein expression analysis, proteomics, and other omics platforms.
• Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design.
• Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• M.S. + 5 or more years of experience or PhD +3 or more years of experience within a scientific discipline (preferably renal or related field) with relevant laboratory experience.
• Three or more years of experience with handling of primary human cells and laboratory techniques such as immunoassays (ELISA, MSD), qPCR, multi-color flow cytometry, and gene expression analysis.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• One or more years of experience in Renal disease.
• Excellent problem-solving skills and ability to critically analyze scientific data.
• Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.
• Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards.
• Able to independently define strategic approach to tackle specific project or department goals.
• Ability to work independently as well as collaboratively in a team-oriented environment.
• Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at [email protected] where you can also request a call.

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