VP, Chief AI Architect

ROLE SUMMARY

Pfizer is seeking a Vice President, Chief AI Architect to define and steward the enterprise AI architecture vision, roadmap, and governance that enable breakthroughs at scale across R&D, Manufacturing, and Commercial. This role brings integrated, end-to-end thinking across data, models, platforms, and products; curates innovation from a strong external network; and ensures secure, reliable, cost-effective patterns for AI solutions (including LLMs and agentic systems) in a regulated environment.

The Chief AI Architect partners closely with the Head of AI CoE (who builds and operates our AI platforms) to ensure that reference architectures, standards, and guardrails are translated into scalable, reusable capabilities. Together, they accelerate adoption, improve reliability and time-to-value, and uphold Responsible AI principles.

ROLE RESPONSIBILITIES

Enterprise AI Architecture Vision & Strategy

• Define the target-state AI architecture (data, model, application, and infrastructure layers) that integrates advanced analytics, ML/LLM, knowledge/semantic technologies, and operational systems.

• Establish the North Star for foundational capabilities: RAG and retrieval pipelines, agents/orchestration, vector search, feature stores, model registries, observability, evaluation, safety layers, etc.

• Set architecture principles that balance innovation speed with compliance, reliability, and total cost of ownership.

Reference Architectures, Patterns & Standards

• Publish reference architectures and blueprints for priority use cases (e.g., scientific discovery assistants, GxP-impacted automation, manufacturing QA, field engagement copilots).

• Define LLMOps/MLOps standards (model lifecycle, evaluation, red-teaming, monitoring, rollback, drift, lineage, documentation).

• Codify security, privacy, and Responsible AI guardrails: data minimization, isolation patterns, PII/PHI handling, human-in-the-loop, explainability, auditability, model risk controls.

Roadmap & Architecture Governance

• Own the enterprise AI architecture roadmap; align with business strategy and portfolio funding.

• Chair an AI Architecture Review Board (AARB) and design authorities that provide fast, pragmatic guidance and approvals.

• Manage technology lifecycle (emerging - adopt - scale - retire) for AI frameworks, model classes, toolchains, and platforms.

Innovation Scouting & External Ecosystem

• Maintain a strong external network (hyperscalers, model labs, hardware vendors, startups, academia, standards bodies) to scout, evaluate, and curate innovations.

• Run evidence-based proofs-of-value and bake successful patterns into the reference stack; shape build/partner/buy decisions with the Head of AI CoE and Procurement.

• Represent Pfizer's interests in industry consortia and standards discussions; encourage selective open-source contribution where it benefits the enterprise.

Partnership with the Head of AI CoE (Operating Model)

• You set the blueprint; the CoE builds/operates. Co-own the platform backlog prioritization and ensure reference patterns - productized capabilities.

• Define SLAs/SLOs, performance benchmarks, and cost guardrails in collaboration with the CoE and SRE/FinOps.

• Jointly drive developer enablement: SDKs, templates, golden paths, sandboxes, and documentation.

Risk, Compliance & Validation by Design

• Embed model risk management, validation evidence, and audit-ready documentation into patterns-fit for GxP, 21 CFR Part 11, GDPR/HIPAA contexts as applicable.

• Institutionalize AI safety: pre-production evaluations, content safety, adversarial testing, policy enforcement, incident response playbooks.

Interoperability & Reuse

• Promote API-first and event-driven integration between AI services and enterprise systems; enable semantic/knowledge layers to unify context across domains.

• Maximize reuse via shared components (prompt libraries, evaluation suites, connectors, datasets, ontologies), tracked through measurable reuse rates.

Performance, Capacity & Cost Engineering

• Set performance engineering practices for training, fine-tuning, and inference (e.g., quantization, distillation, caching, batching).

• Partner with Infra/Cloud/HPC on capacity planning (GPU/accelerator utilization), autoscaling, and cost/per-inference optimization.

Talent, Community & Enablement

• Build an AI Architecture Guild that mentors domain architects and product teams.

• Develop playbooks, training, and office hours to raise architectural quality and speed across the enterprise.

QUALIFICATIONS

Basic Qualifications

• BS/BA degree required, higher degree preferred or relevant experience, 15+ years in architecture or advanced engineering leadership, with 7+ years designing AI/ML platforms and solutions at enterprise scale.

• Demonstrated mastery across LLMs/foundation models, retrieval/RAG, agents/orchestration, evaluation, model safety, and LLMOps/MLOps.

• Deep experience in regulated environments (life sciences/healthcare or equivalent), including validation, auditability, and documentation rigor.

• Proven ability to create reference architectures and standards and drive adoption through governance that enables speed (not bureaucracy).

• Strong external network and a track record of curating innovation (ecosystem scouting, PoVs, build/partner/buy).

• Hands-on credibility with modern stacks: vector databases, feature stores, model registries, observability, event-driven and API-first integration, cloud/HPC, and performance engineering for training and inference.

• Exceptional influence and storytelling skills; able to align senior stakeholders and simplify complex trade-offs.

Preferred Qualifications

• Prior leadership of enterprise or domain architecture for AI-heavy portfolios.

• Contributions to open-source, standards, reference implementations, or published thought leadership.

• Familiarity with data mesh/semantic layers/knowledge graphs, and FinOps/SRE practices for AI platforms.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Travel up to 20% may be required for business activities.

Supervision

Total number of colleagues managed would be 28. Direct reports would be three Directors and three Senior Managers.

OTHER INFORMATION

The following information, if applicable, must be manually inserted into the job description for transparency:

• May be eligible for Relocation benefits

• Hybrid work schedule

• Posting expiration date is March 16, 2026

The annual base salary for this position ranges from $274,000.00 to $426,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 30.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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