Global Senior Reliability Engineer- GxP Life Sciences/ Pharmaceutical

CBRE
Lansdale, PA

CBRE Global Workplace Solutions (GWS) works withclients to make real estate a significant contributor to organizationalproductivity and performance. Our account management model is at the heart ofour client-centric approach to delivering integrated real estate solutions.Each client is entrusted with a dedicated leader and is supported by regionaland global resources, demonstrating the industry's most robust platform. CBREGWS delivers consistent, measurably superior outcomes for our clients at everystage of the lifecycle, and across industries and geographies.

About this role

Weare seeking a highly experienced and strategically focused Global SeniorReliability Engineer with a paramount focus on cost efficiency and a proventrack record in the GxP pharmaceutical environment. This role is crucial inoptimizing the reliability, performance, and associated costs of our mainbuilding installations, critical utility systems, and facility infrastructureacross our global footprint. The successful candidate will leverage deepexpertise in Lean Six Sigma methodologies, process re-engineering, and advanceddata analytics, with strong proficiency in SAP, to identify and mitigatereliability risks, significantly reduce operational expenditures, and ensuresustained compliance with stringent GxP regulations. This is a strategic rolerequiring a minimum of 10-15 years of relevant experience in a complex, globalpharmaceutical setting, with a specific emphasis on facilities and criticalbuilding systems.

What you'll do

  • Cost-Efficient Reliability Strategy for Building Installations : Develop, implement, and lead global reliability strategies specifically for main building installations, critical utilities (e.g., HVAC, WFI, clean steam, compressed air, electrical distribution), and other facility infrastructure. Drive initiatives to achieve substantial cost savings by optimizing maintenance practices, reducing energy consumption, and minimizing unexpected repairs and associated downtime costs. This includes rigorous tracking of maintenance costs for building systems to identify and reduce inefficiencies.

  • Process Re-engineering & Continuous Cost Improvement : Lead process re-engineering initiatives focused on enhancing the reliability and cost-efficiency of facility operations and maintenance workflows. This involves reviewing and updating maintenance strategies for building systems using methodologies like RCM/FMEA and re-engineering preventive and predictive maintenance programs for technical accuracy, effectiveness, and cost optimization. Drive continuous improvement through Root Cause Analysis (RCA) and Root Cause Failure Analysis (RCFA) for facility-related issues, aiming to eliminate repetitive failures and address problems affecting regulatory compliance and operational costs.

  • Lean Six Sigma & Data-Driven Cost Reduction : Apply Lean Six Sigma methodologies (Green Belt or Black Belt certification highly preferred) to identify root causes of failures in building installations, minimize operational variability, and optimize facility-related processes for cost efficiency. Utilize advanced data analysis techniques, including statistical process control, reliability modelling, and Weibull analysis, to monitor building system performance, predict failures, and inform strategic decisions that drive cost reductions.

  • GxP Compliance & Risk Management for Facilities : Ensure all reliability engineering activities related to building installations and critical utilities strictly comply with GxP standards and regulatory requirements (e.g., cGMP, GLP, FDA, EU). Develop and manage risk mitigation plans to anticipate and address reliability-related risks that could impact facility operations, product quality, and regulatory standing.

  • SAP & Data-Oriented Maintenance Optimization : Leverage SAP (specifically the PM module) and other Computerized Maintenance Management Systems (CMMS) for comprehensive asset master data management, maintenance planning, and tracking of reliability KPIs specifically for building installations. Utilize data from these systems to analyse trends, optimize spare parts inventory for cost-effectiveness, and drive insights for continuous cost and reliability improvements.

  • Global Collaboration & Support for Building Systems : Provide expert technical support and guidance to global facility, maintenance, and engineering teams regarding the reliability and cost-effective operation of main building installations and utility systems. Work collaboratively with cross-functional teams to integrate best practices into all aspects of facility operations and maintenance.

What you'll need

  • Education : Bachelor's degree in Engineering (Mechanical, Electrical, Facilities, Industrial, or related field). Master's degree is a plus.

  • Experience : Minimum of 10-15 years of progressive experience in Reliability Engineering, with a significant portion focused on facilities, critical utility systems, and main building installations within the GxP pharmaceutical or biopharmaceutical manufacturing industry.

  • Technical Expertise :

Demonstrated expertise in Lean Six Sigma(Green Belt or Black Belt certification highly preferred) and its applicationto cost reduction.

Extensive experience with reliabilitytools and methodologies such as FMEA, RCM, RCA, Weibull Analysis, StatisticalProcess Control, and predictive maintenance techniques, particularly as appliedto building systems.

Strong proficiency in SAP (PM module)and other CMMS for asset management, maintenance planning, and data analysis offacility assets.

Proven ability to interpret and utilizecomplex data sets to drive reliability improvements and significant costreductions for facility operations.

Thorough understanding of GxPregulations (cGMP, GLP) and their specific application to pharmaceuticalfacilities and utility systems.

Strong understanding of building systemsincluding life-safety, lighting, mechanical, electrical, plumbing, HVAC, andcritical utility systems such as WFI, clean steam, compressed gas, and vacuum.

  • Soft Skills :

Exceptional analytical andproblem-solving skills with a strong data-driven approach to cost efficiency.

Strong communication, presentation, andinterpersonal skills, with the ability to influence stakeholders at all levelsin a global organization.

Demonstrated ability to lead and drivechange in a complex, multi-site facility environment.

Self-motivated, adaptable, and capableof managing multiple priorities with a focus on delivering financial results.

  • Travel : Ability to travel internationally up to 30% to support global sites and facility projects.

About CBRE:

When you join CBRE, you become part of a global leaderin commercial real estate and investment services that help businesses andpeople thrive. We are dynamic problem solvers and forward-thinkingprofessionals who create significant impact! Our collaborative environment isbuilt on our shared values - respect, integrity, service, and excellence - andwe value the varied perspectives, backgrounds, and skills of our people. AtCBRE, you have the opportunity to chart your own course and realize your full potential!

Disclaimer:

Applicants must be currently authorized to work in theUnited States without the need for visa sponsorship now or in the future.

CBRE carefully considers multiple factors to determine compensation, including a candidate's education, training, and experience. The minimum salary for the Reliability Program Director position is $155,000 annually and the maximum salary is 175,000 annually. The compensation offered to a successful candidate will depend on their skills, qualifications, and experience. Successful candidates will also be eligible for a discretionary bonus based on CBRE's applicable benefit program. This role will provide the following benefits: 401(K), Dental insurance, Health insurance, Life insurance, and Vision insurance.

Equal Employment Opportunity: CBRE is an equal opportunity employer that values diversity. We have a long-standing commitment to providing equal employment opportunity to all qualified applicants regardless of race, color, religion, national origin, sex, sexual orientation, gender identity, pregnancy, age, citizenship, marital status, disability, veteran status, political belief, or any other basis protected by applicable law.

Candidate Accommodations: CBRE values the differences of all current and prospective employees and recognizes how every employee contributes to our company's success. CBRE provides reasonable accommodations in job application procedures for individuals with disabilities. If you require assistance due to a disability in the application or recruitment process, please submit a request via email at [email protected] or via telephone at +1 866 225 3099 (U.S.) and +1 866 388 4346 (Canada).

CBRE, Inc. is an Equal Opportunity and Affirmative Action Employer (Women/Minorities/Persons with Disabilities/US Veterans)

Posted 2026-03-12

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