Mass Spectrometry Senior Scientist

System One
Pittsburgh, PA
Title: Mass Spectrometry Senior Scientist

Location: Onsite, Pittsburgh, PA 15232

Type: 6-month contract to hire

Hours: 8AM-5PM

Start: December



Overview:
Join in establishing a state-of-the-art, multi-omics facility to support research and clinical translational programs in multiple OMICS disciplines, including proteomics, metabolomics, and lipidomics. We are seeking a highly skilled and motivated Senior Scientist for the Mass Spectrometry Facility to oversee day-to-day operations while remaining actively involved in sample processing and instrument analysis. Interested in learning more? Please apply today!

Responsibilities
  • Act as the go-to subject matter expert for mass spectrometry, including custom method development, automation initiatives, and troubleshooting to enhance analytical precision and continuous improvements in mass spectrometry-based omics.
  • Ideal candidate should be able to identify erroneous results and execute rapid fault-diagnosis, root-cause identification, and corrective action on mass spectrometers.
  • Perform hands-on work in all aspects of LC–MS/MS workflows, including sample preparation, method development and setup, and data acquisition.
  • Train, mentor, and supervise technical staff; foster a culture of precision, accountability, and teamwork.
  • Collaborate with researchers to design, optimize, and execute mass spectrometry based studies.
  • Ideal candidate should have experience operating, maintaining, calibrating, and troubleshooting mass spectrometers.
  • Maintain accurate records of instrument performance, sample tracking, and results within the Laboratory Information Management System (LIMS).
  • Proven practice in using samples, controls, and standards to create robust reference materials to accurately review and analyze output data.
Requirements
  • PhD or Master’s degree with 5 years experience in biochemistry, analytical chemistry, or a related field.
  • Minimum of 5 years’ experience operating and maintaining mass spectrometers.
  • Preferably 3 + years in a core facility environment working with Thermo Mass Spectrometry instrumentation, with demostrated experience in method development.
  • Proven experience in LC–MS sample preparation, data acquisition, and troubleshooting.
  • Demonstrated ability to manage staff and workflow while maintaining personal engagement in laboratory operations.
  • Strong organizational, problem-solving, and communication skills.
  • A proactive mindset, able to adapt and perform under pressure. Specifically, demonstrate ability to operate in a fast-paced, high-throughput core facility environment.
  • Driven and detail-focused scientist who thrives in a collaborative and high-throughput lab environment.
System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.

#M3
#LI-DS1

Ref: #558-Scientific

Posted 2025-11-14

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