Director of Clinical Pharmacology and Quantitative Medicine

Site Name: USA - Pennsylvania - Upper Providence

Posted Date: Feb 3 2026

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients’ needs and have the highest probability of success. We’re uniting science, technology, and talent to get ahead of disease together.



Job Purpose

You will lead clinical pharmacology and quantitative medicine activities that guide drug development decisions. You will work with cross-functional teams to design trials, build models, and translate data into clear dose and study recommendations. We value scientific curiosity, teamwork, and clear communication. This role offers growth, visible impact on patient-focused programs, and the chance to help unite science, technology and talent to get ahead of disease together.



Responsibilities

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Lead development and application of pharmacokinetic, pharmacodynamic and mechanistic models to inform dose selection, trial design and evidence generation.
• Collaborate with clinical, translational, biomarker, regulatory and statistical teams to design efficient clinical development plans.
• Provide quantitative input for regulatory interactions and contribute to submission documents.
• Design and interpret clinical pharmacology studies assessing intrinsic and extrinsic factors, drug-drug interactions, and special populations.
• Promote and implement model-informed drug development approaches, including PK, PKPD, mechanistic and systems models, and foster external scientific collaboration.
• Communicate results clearly to diverse audiences through reports, presentations and scientific publications.

Why You?
We want people who bring technical skills, clear thinking and collegial leadership. This role is hybrid with regular time in the office. Additional flexibility may be considered on a case by case basis.



Basic Qualification
We are seeking professionals with the following required skills and qualifications to help us achieve our goals:

• Advanced degree (PhD, PharmD or equivalent) in clinical pharmacology, pharmaceutical sciences, quantitative biology or related field.
• Minimum 5 years of industry experience in clinical pharmacology and pharmacokinetics/pharmacodynamics modelling and simulation in drug development.
• Hands-on experience with pharmacometrics tools and languages (for example NONMEM, Monolix, R, SAS, MATLAB or similar).
• Proven experience contributing to regulatory submissions or interactions and applying relevant guidance for clinical study design.
• Demonstrated ability to design and interpret clinical pharmacology studies, including evaluation of drug interactions and special populations.
• Strong collaborator who can work effectively across multi-disciplinary teams and communicate complex data clearly.

Preferred Qualification
If you have the following characteristics, it would be a plus:

• Experience with mechanistic, systems pharmacology or quantitative systems models applied to preclinical and clinical questions.
• Experience across multiple drug modalities (small molecules, biologics) and therapeutic areas; preferably antisense oligonucleotides and small interfering RNAs.
• Track record of scientific publications or presentations in pharmacology, modelling or related fields.
• Experience leading project teams or mentoring junior scientists.
• Comfort working with data science or scientific machine learning approaches that support modelling and simulation.

• LI-GSK#

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at [email protected] where you can also request a call.

Please note should your inquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. Click the link where you will find answers to multiple questions we receive

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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